The year is 2020, and Phil Miller (Will Forte) is the only human left on Earth after a deadly virus swept the planet. Previously an average man who loved his family and hated his job, Phil searches the country in his RV for other survivors.
After a long journey and returning to his hometown of Tucson, Arizona, Phil believes that he is almost certainly Earth's last surviving human.
Just before he commits suicide out of loneliness and a desire for a female companion, his wish comes true, but he soon finds that, while he is not the only human left on Earth, he is the only "man" left on Earth.